A Peptidomic Analysis of Human Milk Digestion in the Infant Stomach Reveals Protein-Specific Degradation Patterns

Published in the Journal of nutrition, April 3rd 2014.

In vitro digestion of isolated milk proteins results in milk peptides with a variety of actions. However, it remains unclear to what degree protein degradation occurs in vivo in the infant stomach and whether peptides previously annotated for bioactivity are released. We show that gastric proteolysis occurs in the term infant in the first 2 wk of life, releasing biologically active milk peptides with immunomodulatory and antibacterial properties of clinical relevance to the proximal intestinal tract (1).

You can read more at http://jn.nutrition.org/content/early/2014/04/02/jn.113.185793.short

(1) Dallas, D. C.; Guerrero, A.; Khaldi, N.; Borghese, R.; Bhandari, A.; Underwood, M. A.; Lebrilla, C. B.; German, J. B.; Barile, D., A Peptidomic Analysis of Human Milk Digestion in the Infant Stomach Reveals Protein-Specific Degradation Patterns. The Journal of nutrition 2014.